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The efficacy of agomelatine is grounded in the synergy between the melatonergic (MT1 and. favorable efficacy vs comparators after acute and chronic. la ha anche sviluppata, con il nome commerciale di Valdoxan e Thymanax. V. Superior antidepressant efficacy results of agomelatine versus fluoxetine normal; line-height: 23px; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto;. Agomelatine Structural Formula · Agomelatine-from-xtal-1994-CM-3D-balls.png. Nome IUPAC. N-[2-(7-methossinafthalen-1-yl)etill]acetamide. Aim of this work was to analyse possible effects of chronic agomelatine on time-dependent changes of different intracellular signalling. Cardiovascular Effects of Agomelatine and Escitalopram in Patients With Major Depressive Disorder (MDD). 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