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Fracture Prediction After Discontinuation of 4 to 5 Years of Alendronate Therapy. The FLEX Study. JAMA Intern Med. 2014. Alendronate ( Fosamax ) reduces the ability of Teriparatide ( Forteo Forsteo ) to increase. During the clinical trials, early discontinuation due to adverse events. In the initial efficacy studies, the increases in BMD with alendronate 10 mg daily. Transaminase elevations were reversible upon discontinuation of therapy. •Reasons for discontinuation vary amongst treatments, although the most. bisphosphonates (alendronate or risedronate), or other osteoporosis medications. controllati con placebo su alendronato e rise- dronato, la riduzione. 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