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Antiosteolytic treatment (bisphosphonates denosumab). *Includes increased blood creatinine, renal failure, acute renal failure, proteinuria, renal impairment. con alendronato è risultata monitorabile mediante ultra sonografia ossea. of forearm and hand in patients with end-stage renal failure trea ted with dialysis. Dosing adjustment in renal impairment: Scr Use with caution. Scr >5 Not recommended. Supplied: Injection, solution: 50. RECOMMENDATIONS FOR USE OF BISPHOSPHONATES IN. 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