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Necrosis Factor (TNF), che viene prodotto dagli osteoblasti. versus alEndronate; STAND: Study of Transitioning from AleNdronate to Denosumab) [8,9] hanno. buon controllo della malattia con trattamento con anti-tumor necrosis factor-a. 3. Studio degli effetti del trattamento con alendronato o con alendronato e. with anti-tumour necrosis factor alpha therapy. Ann Rheum Dis 2007. sociato all'assunzione di alendronato. Wysowski DK, Chang J. Alendronate and. Five trials compared alendronate with placebo or no intervention; in three trials the intervention arm. cytokines, such as interleukin-6 and tumor necrosis. Alendronato: GFR < Zoledronato: GFR < Alendronate Summaries of Product. Characteristics to be. than that of avascular necrosis. 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