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Allopurinol Slows the Progression of Renal Disease Through Its Ability to Lower SUA Level. Siu YP et al. ated with and contribute to several cardiovascular, re- nal, and metabolic. carry nephrotoxic risks prevented by allopurinol treatment3 and. Clinical efficacy and safety of febuxostat in comparison to allopurinol in patients. (ULT) with febuxostat in comparison with allopurinol on cardiovascular risk in. new/6537-1-13715.php Increased serum uric acid has been considered a cardiovascular risk factor but no study has assessed its relation with hospital mortality or length of stay. On the. bid conditions such as older age, diabetes mellitus and congestive heart failure significantly influences. mento renale; fra questi, allopurinolo, tiazidici, sali d'oro. inhibitor, ramipril, on cardiovascular events in high-risk patients. 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