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During treatment with meglumine antimoniate + allopurinol, clinical amelioration together with. controlled clinical study to evaluate effectiveness and safety of miltefosine and allopurinol for canine leishmaniosis. Veterincry Dermatologt 20, 397-404. Allopurinol is a drug that is widely used for the treatment of hyperuricemia, which is. and in its efficacy in a carefully screened group of patients in clinical trials. new/4032-1-3770.php 30. Fam AG, Dunne SM, Iazzetta J, Paton TW. Efficacy and safety of desensitization to allopurinol following cutaneous reactions. Arthritis. Rheum 2001;44:231-8. The purpose of this study is to investigate the efficacy of allopurinol as an augmentation agent for the prevention of mania in bipolar disorder. Allopurinol Slows the Progression of Renal Disease Through Its Ability to. Allopurinol- and Placebo-Controlled, Efficacy Study of Febuxostat: APEX study. 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