Xanthine oxidase allopurinol for gout. If the inhibition is studied without pre-incubation of enzyme and inhibitor, allopurinol behaves as though it were as. Mechanism of inhibition of xanthine oxidoreductase by allopurinol: crystal structure. which have previously been shown to be essential for the enzyme reaction. This enzyme normally is present in skeletal and cardiac muscle. Allopurinol is not used for stopping an attack of an episode of gout, instead of protecting. clearance (see Drug Interactions: Hepatic Enzyme Inhibitors). amiodarone dialyzable warfarin and enzyme inducers interaction crestor warfarin. allopurinol interaction warfarin florinef and warfarin. sodium synthesis enzyme inhibitor warfarin. 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