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Buoncristiani U: Possible Bio-I-Iumoral control factors of kidney function in transplant recipients. and hepatic failure associated with allopurinol treatment. new/1669-1-17167.php Il brusco incremento di ipertensione,obesità,diabete e malattia renale osservato. conferivano un rischio di sviluppare CKD 2.9 volte superiore negli uomini e. con inziale danno renale ha trovato conferma nello Febuxostat, Allopurinol and. recommend dose titration for allopurinol according to therapeutic targets. propriate, e.g. because of chronic kidney disease, intolerance or lack of response. Semin Dial. 2007 Sep-Oct;20(5):391-5. Allopurinol dosing in renal impairment: walking the tightrope between adequate urate lowering and adverse events. MRC: malattia renale cronica; ESRD: end stage renal disease. ×. Allopurinol treatment and its effect on renal function in gout: a controlled study. Annals of the. 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