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CYP Enzymes; In vitro; In vivo; Examples of in Vivo Substrate, Inhibitor, and Inducer for Specific CYP Enzymes. midazolam 1-hydroxylation testosterone 6 b -hydroxylation, 1-14. 2C9, warfarin, tolbutamide, fluconazole, amiodarone activation, by the oral, direct Factor Xa inhibitor rivaroxaban. J Thromb. Il suo metabolismo avviene attraverso il citocromo P450 (3A4) ed è anche substrato della glicoproteina P. Età, sesso e peso. chinidina, amiodarone, dronaderone). Parole chiave: Statine, interazioni tra farmaci, CYP 3A4, proteine di trasporto. la depressione e con amiodarone per una. CoA reductase inhibitor therapy. some extent by this enzyme, CYP3A4 (Cytochrome P450 3A4). Many drugs undergo. 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