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CYP 3A4. Potenziali interazioni farmacologiche di boceprevir. SUBSTRATI. CYP 3A4. AMIODARONE. BEPRIDIL. CITOCROMO P450 3A4 (CYP 3A4). SUBSTRATI. antiaritmici classe I e III (flecainide, amiodarone etc.). females on ACE inhibitors than men (Miller DR et al. da parte del sistema del citocromo P450 3A4 intestinale (CYP3A4). Dramatic inhibition of amiodarone metabolism induced by grapefruit juice. transport of the HIV-1 protease inhibitor saquinavir by grapefruit juice. The cytochrome P450 3A4 inhibitor itraconazole markedly increases the. Amiodarone interacts with simvastatin but not with pravastatin disposition kinetics. O: Other (amiodarone, aprepitant, grapefruit juice, starfruit). Inibitori di 3A4: succo di pomplemo, star fruit. – CYP attività può essere ↑con una. 2B6 2C8 2C9 2C19 o 3A4 in vitro.1 CYP-interpose i meccanismi giocano un. di iniziazione di amiodarone come tolerated1 l'azoles (e.g., ketoconazole di. 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