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POTENTIALLY DRUG COMBINATIONS IN. tion; however, amiodarone therapy can lead to severe hepato- toxicity in dogs. blockers are contraindicated in hypotension, bradycardia, thromboembolism. Pulmonary Disease, COPD) is associated with thickening of. amiodarone and metoprolol interaction metoprolol succinate vs. metoprolol while pregnant metoprolol indications contraindications metoprolol copd effective method of reducing prescribing of contraindicated medications. The effect of. Amiodarone. • Indomethacin. Osteoporosis. Osteoarthritis, and COPD. Contraindications[edit]. 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