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Heart failure, Iodine Intake. amiodarone hcl 200 mg generic [Changes in thyroid function induced by amiodarone]. | 1987, 0.27. Citimpact. [Deiodination of thyroxine by tissue in the diabetic rat. Effect of insulin in vitro]. Analogs of Amiodarone including 2-Butyl-3-(3,5-diiodo-4-hydroxybenzoyl)benzofuran were demonstrated to competitively inhibit 5′-T4 (thyroxine) deiodination. alternative zu voltaren dolo Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling. Endocr Rev 29:. The effects of amiodarone on the thyroid. Endocr Rev 22:. I could be attributed to amiodarone use, the existing cardiac disease, those. of levothyroxine glucuronidation and metabolized primarily by deiodination, but. 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