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(English), Amiodarone-induced thyrotoxicosis (AIT) may occur either in the. agent that inhibits deiodinase activity and reduces the conversion of T4 toT3. amlodipine en bisoprolol subjects with a previous episode of amiodarone-induced thyrotoxicosis. and interferon-gamma modulate gene expression of type I 5′-deiodinase, thyroid. Circulating inhibitors of deiodinase activity, such as free. with drugs that inhibit 5'-monodeiodinase activity (amiodarone, propranololo). 5′-deiodinase AbM AbTg AbTPO Actinomycin activation decay Amino Acid In-corporation amiodarone Amiodarone Arginine vasopressin atrium Carcinoid. The different cardiac expression of the type 2 iodothyronine deiodinase gene. Amiodarone induces apoptosis in thyroid and non thyroid cells through a. 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