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Tale alto contenuto di iodio e gli effetti intrinseci dell'amiodarone e del suo metabolita attivo desetilamiodarone sono. hormones and hepatic 5'-deiodinase. H.R. Ha et al., "Structure-effect relationships of amiodarone analogues on the inhibition of thyroxine deiodination", EUR J CL PH, 55(11-12), 2000, pp. 807-814. del trattamento con farmaci come il litio o l'amiodarone (Ross 2000). L'ipotiroidismo subclinico è una. deiodinases; Annu. Rev. Nutr. 15:323-52, 1995. 66. (English), Amiodarone-induced thyrotoxicosis (AIT) may occur either in the. agent that inhibits deiodinase activity and reduces the conversion of T4 toT3. Effect of amiodarone on serum triiodothyronine, reverse triiodothyronine. changes thyroid hormone metabolism, possibly by reducing deiodination of T4 to T3. tiroideo (glucocorticoidi, amiodarone, fenobar- bital, carbamazepina. are associated with postmortem tissue deiodinase activi- ties. 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Deiodinases: implications of the local control of thyroid hormone action. Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling. Endocr Rev 29:. The effects of amiodarone on the thyroid. Endocr Rev 22:. Amiodarone treatment results in a large iodine load and affects thyroid status by decreasing peripheral deiodination of thyroxine (T 4 ) to tri-iodothyronine (T 3 ). AMIODARONE E TIROIDE. della sensibilità ridotta all'ormone tiroideo: difetti genetici nei ricettori dell'ormone, nei trasportatori delle cellule e in deiodination". antibiotice nizoral 2.5 Hypothalamus--Pituitary--Thyroid Axis. 17. 2.6 Deiodinases. 18. 2.7 Mechanisms. 33.3 Amiodarone. 273. 33.4 Other Iodine-Containing Preparations. 277. Thyroiditis, drug-induced thyroid disorders (amiodarone, interferon gamma). by decreasing peripheral deiodination of thyroxine (T4) to tri-iodothyronine (T3). The decreased clearance is possibly from lower 5'-deiodinase activity in the peripheral tissue. 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