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It is also a potent inhibitor of 5′-deiodinase, preventing conversion of T4 to T3. radioiodine, deiodinases, clinical symptoms, heart rate, HF, systolic function, diastolic function, systemic vascular resistance, endothelial function, amiodarone. Effect of amiodarone on serum triiodothyronine, reverse triiodothyronine. changes thyroid hormone metabolism, possibly by reducing deiodination of T4 to T3. Inhibition of this deiodination step by drugs—the antiarrhythmic drug amiodarone (vedi diapositiva 7.3.6) in particular—causes a functional thyroid hormone. In particolare, venicano esclusi i pazienti in terapia con amiodarone, propranololo. Deiodinases: implications of the local control of thyroid hormone action. (2009) Effects of amiodarone therapy on thyroid function. Nat. Rev. converted to T3 predominantly by type I iodothyronine deiodinase. Abbreviations: D1, type I. 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