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Kaplan-Meier curves for digoxin use and all-cause mortality in AF. Digoxin interaction with coumadin amiodarone digoxin interaction digoxin and. Atrial fibrillation (AF) is a major cause of morbidity and mortality and affects of. Digoxin is used for treating heart failure and slowing the heart rate in patients with chronic atrial fibrillation, a type of abnormal heart rhythm. Digoxin is a digitalis. Is amiodarone superior to digoxin in achieving faster and safer control of ventricular rate in patient with atrial fibrillation and left ventricular. amiodarone, and digoxin for the reversion of new-onset atrial fibrillation. Ann Emerg Med 2000;36:1-9. Roy D, Talajic M, Dorian P, et al. Amiodarone to prevent. Results: Women were older, had a higher prevalence of atrial fibrillation, and more. amiodarone, and spironolactone, and more frequently prescribed digoxin. new/4573-1-3295.php Prevalence of Atrial Fibrillation by Age and Sex. 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