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No need. Digoxin. (P-GP substrate). • Amiodarone. (moderate to strong P-gp inhibitor). Mechanism of Interaction: Multiple theories exist, but actual mechanism is unknown. Amiodarone may decrease the clearance of digoxin, resulting in prolonged. Bryant, D. Hammond, Interaction of purulent material with antibiotics used to treat. parameters of digoxin used in combination with gentamicin, amiodarone and. Caution should be exercised when administering Rebif in combination with. index, for example, antiarrhythmic agents Class III including amiodarone. Given that digoxin has as a narrow therapeutic index, it is recommended that the lowest. Caution should be used when combination therapy with digoxin and amiodarone is chosen for rate control because amiodarone can significantly increase SDC. Collagen Human fibrinogen "; Combination Fibrinogen+Thrombin;. 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