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AF recurrence or premature drug discontinuation for intolerance or inefficacy. periods at low doses or may even arise after discontinuation of treatment. or Class III antiarrythmics (e.amiodarone, sotalol), antipsychotic medications (e, 25. cloranfenicolo, Claritromicina inibitori proteasi Verapamil, Amiodarone. during Treatment and after Discontinuation in the Intention-to-Treat Population. 2013; Effects of dronedarone started rapidly after amiodarone discontinuation. 2013; Long-term complications related to biventricular defibrillator implantation:. Study discontinuation for excess mortality associated with encainide and flecainide after a 10 months follow-up. – SCD RR = 3.6 (1.7-8.5). Number of deaths. Amiodarone-induced concomitant first and second degree sinoatrial block. Discontinuation of amiodarone resulted in the disappearance of such a sinoatrial. 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