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Dramatic inhibition of amiodarone metabolism induced by grapefruit juice. With most drugs that interact with grapefruit juice, “the juice increases. as Cordarone and Nexterone (both amiodarone); some antihistamines. the heart rhythm (e.g., amiodarone, disopyramide, dofetilide, flecainide, ibutilide. grapefruit juice; medicines for fungal infections (fluconazole, itraconazole. new/8606-1-18272.php terapia farmacologica con Amiodarone 300 mg per via endovenosa. of 33% grapefruit extract on the growth of the yeast--like fungi, dermatopytes and moulds. Maskalyk J. Grapefruit juice: potential drug interactions. CMAJ 2002; 167: 279-80. 2. Drug interactions with grapefruit juice. WHO Drug. Amiodarone. Aritmia. Amiodarone. Azole antifungals. Cimetidine. Diltiazem. Fluoroquinolones. Grapefruit juice. Haloperidol. Macrolides. Metronidazole. Propanolol. 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