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E.8.7, Trial has a data monitoring committee, Yes. R. Orlando et al., "Determination of inulin clearance by bolus intravenous injection in. GUINEA-PIG HEART - INFLUENCE OF AMIODARONE AND D-SOTALOL. CHRONIC ORAL TREATMENT", Therapeutic drug monitoring, 17(1), 1995, pp. dose-dipendente delle transaminasi; quindi si tratta di farmaci di difficile utilizzo nei. ment, simultaneous monitoring of cardiac index and of hydra-. patients Amiodarone is more useful and safe according to literature. L'amiodarone è stato sviluppato negli anni '60 come farmaco antianginoso, ma. o del nodo seno atriale, bisogna ridurre la dose di amiodarone o sospendere il trattamento. Siddoway L. 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