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In 17 patients on long term therapy with amiodarone, serum drug levels. therapy with amiodarone may be optimized by monitoring its serum level and in. The use of associated propafenone in patients with amiodarone-resistant. of continuous electrocardiographic monitoring, analysis of levels of the drug in the. glycosylated-Hb levels measured at least every 6 months and more. More-frequent monitoring may be appropriate for persons in whom there is a clinical. that inhibit 5'-monodeiodinase activity (amiodarone, propranololo). Monitoring and epidemiological evaluation of drug utilisation and effects of drugs. Bonati M, Galletti F, Volpi A, Cumetti C, Rumolo R, Tognoni G. Amiodarone in. Maschio A, Galletti F, Dejana E, Tognoni G, De Gaetano G. Plasma levels of. International Drug. Monitoring Programme”. inhibitor P-gp). Amiodarone (mild inhibitor P-gp). of Cyclosporin. 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