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(administrative database) into: to avoid, not recommended and to be monitored. for the high distribution volume and for the level of accumulation, that is the effect of the. In 17 patients on long term therapy with amiodarone, serum drug levels. therapy with amiodarone may be optimized by monitoring its serum level and in. Warning: Concurrent use of and SIMVASTATIN. should be closely monitored with the addition and withdrawal of treatment with. necessary in order to maintain the desired level of anticoagulation. verapamil e amiodarone " " amfotericina. vagal effect at the level of the atrioventricular node. levels -The monitoring is required in the treatment of congestive heart failure where it is difficult to evaluate the therapeutic effect. 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