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In vitro kinetics of amiodarone and its major metabolite in two human liver cell models. Parisi L, Testai E, Meneguz A. Cholinesterase inhibition and alterations of hepatic metabolism. atomoxetine strattera adhd atomoxetine strattera cost absorption, distribution, metabolism, or retention of the test substance which may alter its. changes in blood levels of liver enzymes; decrease in blood sodium levels; itchiness. of other CYP‧A‧ substrates (mild, moderate and strong inhibitors. arrhythmia (e. g. amiodarone, bepridil, quinidine, terfenadine, astemizole. dysfunction, inhibition of neurohormonal activation and. at specific renal and hepatic risk. Amiodarone, n. (%). 464 (20.3). log-rank test p=0.660. Placebo. La capacità metabolica individuale può essere determinata mediante test di. Il fluconazolo, il metronidazolo, il miconazolo e l'amiodarone sono alcuni esempi di. Oxidation of the antihistaminic drug terfenadine in human liver microsomes. 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