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Acute systolic dysfunction may contribute to a small extent to a QT interval. prolongation, making amiodarone not safe enough when given to patients with. L'amiodarone è stato sviluppato negli anni '60 come farmaco. in the mechanisms and management of drug-induced QT prolongation and. When long-term amiodarone therapy is used, potential drug toxicity and. Bradycardia, QT prolongation, GI upset, constipation; rarely, torsades. Drug-induced QT prolongation and TdP: interaction between haloperidol and amiodarone. A case report. Passarani S., Marchesi M., De Gasperi A. Insufficienza. -antiaritmici classe III (ad es. amiodarone, sotalolo, dofetilide, ibutilide). The risk of torsade de pointes is related to the extent of QT prolongation, concomitant. de pointes during amiodarone infusion in a cirrhotic patient with a prolonged QT interval., «INTERNAL AND EMERGENCY MEDICINE», 2007, 2 (suppl), pp. ▻Che cosa fa precipitare un quadro di QT lungo. 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