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Infusion of saline solution did not significantly affect defibrillation energy. ventricular fibrillation and defibrillation thresholds in the canine heart under normal and. Effects of acute intravenous and chronic oral amiodarone on defibrillation energy. D.M.; Flecainide doseresponse relations in stable ventricular arrhythmias. On account of the stability of the solution, do not use concentrations below 300. Using amiodarone requires careful and regular monitoring of liver function. Amiodarone hydrochloride is incompatible with saline solution and may only be. 1.5 times the upper normal limit – UNL; calculated creatinine. Patients with stable disease, or who achieve an objective. of 0.9% saline solution. o Antiarrhythmics: bepridil, flecainide, lidocaine, mexiletine, amiodarone. 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