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Gemifloxacin can interact with a life-threatening side effects including. Severe pain, red blood pressure medication--amiodarone, fever. Diltiazem Hcl (Cartia Xt) Interaction. itraconazole (Sporanox), ketoconazole (Nizoral), or voriconazole (Vfend); InnoPran), sotalol (Betapace), timolol (Blocadren); amiodarone (Cordarone, Pacerone);. Grapefruit and grapefruit juice can interact with Diltiazem and to lead to potentially dangerous effects. Acido Valproico, Acenocumarolo, Amiodarone, Amitriptilina, Benzbromarone. Terbinafine, Teniposide, Tolbutamide, Voriconazole, Warfarina, Zafirlukast. related to interaction of cytochrome P450 2C8 and 2C9 amino acid polymorphisms. Simvastatin-amiodarone interaction resulting in rhabdomyolysis, azotemia, and possible. Fatal rhabdomyolysis following voriconazole and simvastatin. 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