Heart. 2003;89:848-853. NHS* expenditure for angina, in millions of pounds (dollars). General practice. Microvessels stenosis;. • Aterosclerotic disease. *Except amlodipine. Boden WE et al. contraindication to the use of beta-blockers. Serum calcium concentration is not affected by amlodipine. diuretics beta-blockers is contraindicated or in patients with medical conditions in which. 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