Enzyme Inhibitor or Calcium Channel Blocker vs Diuretic. 6-year rate of HF with amlodipine (10.2% vs 7.7%; RR, 1.38; 95% CI, 1.25-1.52). Titolo: Comparison of the effects on 24-h-ambulatory blood pressure of valsartan an amlodipine, alone or in combination with a low-dose diuretic, in elderly. No overall differences in the efficacy or safety of amlodipine, valsartan, hydrochlorothiazide. hyponatremia) and dehydration resulting from excessive diuresis. Calcium-antagonists, diuretics, beta-blockers, alpha-1 blockers, sympathomodulators. degli eventi cardiovascolari del 30% superiore rispetto all'amlodipina. Effects of a fixed-dose ACE inhibitor-diuretic combination on ambulatory. with the calcium channel blocker (amlodipine, 5 mg titrated up to 10 mg) and diuretic. strato una “forchetta” molto meno evidente (10.2% con amlodipina vs. treatment with a long-acting calcium-channel blocker or diuretic in the. Apart from certain diuretic-based combinations, the use of combinations of. 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