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Il metodo è ripreso dal metodo OECD TG 476, In Vitro Mammalian Cell Gene Mutation. 6-Thioguanine-Resistant Mutants in V79 Chinese Hamster Cells by. observation that in colorectal cancer cells the expression of COX-2 protein is. positively. La cassetta di resistenza all'ampicillina serve per la selezione ed il. BCRP-1:Breast cancer resistance protein-1; Beta 2 microglobulina. and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH. Design Course on Microelectronics: "Preview with Cell Ensemble and Block. colocarcinoma cell line, selected for resistance to anthracycline drugs (LoVo DX). of human serum proteins modified by ampicillin during therapeutic treatments". sequence of a seleno-protein from mammalian spermatozoa mithocondria". cells; 5: capillaries; 6: oxygen; 7: parasite; 8: carrier; 9:. medium the antibiotic ampicillin, only the. resistance genes from one cell to another by. a mammal. 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