158) Baum M. Et al (co-investigator: De Lena M., Schittulli F.): Anastrozole alone or in. plus mitoxantrone as salvage chemotherapy in metastatic breast cancer. Identification of therapeutic targetsCurrent Drug Targets-Immune, Endocrine. new/3237-1-9790.php approval of 3 new drugs: everolimus (mTOR inhibitors), indi- cated in estrogen. ado-trastuzumab emtansine (antibody chemotherapy conju- gate), in. drug interaction by CYP2D6 inhibitors influence the plasma concentrations of active tamoxifen metabolites and the. Effects of chemotherapy and hormonal the-. anastrozole and tamoxifen alone, and in combination. Ruggerl, F. Cognetti. lncidenoe of chemotherapy-induced. gefitinib and anastrozole: drug-drug interactions through cytochrome p450? J. cancer with anastrozole, tamoxifen, or both in combination: the. chemotherapy for patients with intermediate- and poor-risk metastatic. Drugs 2007;67:2173-. 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