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A Phase II randomized trial of anastrozole versus anastrozole and fulvestrant as first-line therapy for. Early results of the Arimidex, Tamoxifen, Alone or in Combination (ATAC) trial showed that anastrozole has a superior efficacy and fewer adverse effects. controlled versus placebo, phase II study to evaluate the efficacy of RAD001 combined. Astrazeneca: ITA: The Italian tamoxifen anastrozole trial” : an Italian. MCRN004 : An Open-label, Non-comparative, Multi-centre Study to Assess the Efficacy and Safety of Bicalutamide When Used in Combination With Anastrozole. Switching to anastrozole versus continued tamoxifen treatment of early breast. a prospective randomized trial to test the efficacy of switching postmenopausal. action and thus have consequences in the efficacy and toxicity of treatment. Anastrozole alone or in combination with tamoxifen versus. hormone receptors and other factors to the efficacy of adjuvant tamoxifen:. 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