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C. difficile--associated disease (CDAD) ranges in severity from mild diarrhea to fulminant colitis and death. Antimicrobial use. with metronidazole or vancomycin. La colite pseudomembranosa (CP)o “Clostridium Difficile associated. vancomicina e metronidazolo; nelle forme più gravi e nelle forme complicate il. The spectrum of Pseudomembranous enterocolitis and antibiotic associated diarrhea. The term antibiotic-associated diarrhea (AAD) refers to a benign, self-limited. Oral vancomycin and metronidazole used for 7 to 10 days are considered the first. Chretien, Metronidazole-associated aseptic meningitis. in Clin Infect Dis, vol. Pelli, [Antibiotics and pseudomembranous colitis]. in Recenti Prog Med, vol. 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