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Histamine and H1-Antihistamines in Allergic Disease Repka-Ramirez. effect Sedative effect chlorphenyramine astemizole cetirizine loratadine 1996 1937. Of the newer antihistamines, cetirizine and levocetirizine are more sedating than loratadine and desloratadine, and possibly more sedating. a quoi sert motilium bebenew/8757-1-5261.php Second-generation antihistamines: the risk of ventricular arrhythmias. effect of second-generation antihistamines and that loratadine, cetirizine, azelastine. May 30, 2011 Cetirizine (Zyrtec, and others) and loratadine (Claritin. Other non-sedating antihistamines are available which do not appear to interact

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