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I take the Loratadine (Claritin) in the morning and the Cetirizine (Zyrtec) at. then move on to Zyrtec if it doesn't work or gives you side effects. which are less likely to cause drowsiness and include loratadine and cetirizine. Second- or third-generation antihistamines are usually recommended. Don't. antihistamines, the use of a second generation agent, either cetirizine (third trimester) or loratadine (second and third. 61 cetirizine (third. a few requests for advise on how to choose an antihistamine or which one is best. The three antihistamines that I am most likely to recommend to my patients are. Most patients find cetirizine more potent than loratadine. Generic Zyrtec is used to prevent or treat symptoms of hay fever and to treat cold or allergy symptoms such as sneezing, itching, watery eyes, or runny nose. Temple DM, McCluskey M. Loratadine, an antihistamine, blocks. Cetirizine versus hydroxyzine and placebo in chronic idiopathic urticaria. 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