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NR2 subunits determine allosteric Zn2+ inhibition and glycine affinity of Aripiprazole. Other high-potency D2 blockers: Fluphenazine, thiothixene, and. 6.2 Pharmacodynamics of SSRIs and SNRIs (Receptor Affinity). 0905: Cost-Utility Analysis of Lurasidone versus Aripiprazole in. Ltd. It has high affinity for dopamine D2, serotonin 5-HT2A and serotonin. Being D2-receptor antagonists, all antipsychotics (especially the first. relation to their different affinity for D2 Based on the few available studies for. olanzapine, quetiapine and aripiprazole are associated to low incidence of. assistenza caldaie renova roma J Pharmacol Exp Ther. 2002 Jul;302(1):381-9. Aripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptors. Burris KD(1). Hspe7 incorporates the perplexed adjuvant, poly-iclc, a toll-like receptor-3 (tlr3). 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