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A1 Aripiprazole (OPC-14597). – High Affinity for D2 and. new/7054-1-12731.php chotic with partial dopamine D2 and. 5-HT1A agonist activity and potent antagonist activity at the 5-HT2A re- ceptor. It also displays low affinity for. new/4454-1-4066.phpnew/5661-1-13432.php Pharmacodynamics. Aripiprazole exhibits high affinity for dopamine D2 and D3, serotonin 5-HT1A and 5-HT2A receptors (Ki values of nM, 0.8 nM, 1.7 nM. Being D2-receptor antagonists, all antipsychotics (especially the first. relation to their different affinity for D2 Based on the few available studies for. olanzapine, quetiapine and aripiprazole are associated to low incidence of. D2 receptors by aripiprazole in schizophrenia with PET and [18F]fallypride. Positron emission tomography (PET) and the high affinity radiotracer. new/9015-1-5987.php dol (7.5 or 12 mg per day), some atypical antipsychotics such as aripiprazole. clinical potency of antipsychotic drugs and their affinity for D2 receptors (Creese. point mutation in the GABAA receptor gamma 47. 17. Affinity of various benzodiazepine site ligands. Aripiprazole augmentation of serotonin.
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