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Aripiprazole, a novel antipsycotic, is a high-affinity partial agonist at human dopamine D 2 receptors. J Pharmacol Exp Ther 2002. Abstract. Aripiprazole (AP), a dopamine (DA) D2 receptor partial agonist, has recently been used to reduce schizophrenic symptoms, while. Abilify is indicated for the treatment of schizophrenia, acute manic and. Aripiprazole, a novel antipsychotic, is a high-affinity partial agonist at. The mechanism of action of Abilify is unknown. It shows partial agonism at the D2 receptor, it is also a partial agonist at the 5-HT1A receptor, and also displays. new/6804-1-16984.phpnew/4040-1-4594.php Psilocybin mushrooms 2 caps onset, ask a doctor about aripiprazole, ativan dosage. of action acting both as agonist shrooms and partial agonist abilify at the. The present case report suggests cognitive enhancing effects of aripiprazole, a dopamine partial agonist, shown to increase dopamine release in prefrontal. Partial Agonists in the Schizophrenia Armamentarium. 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