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A case of Cotard's Syndrome successfully treated with aripiprazole. of antipsychotic-induced hyper-prolactinemia: The role of partial agonists of D2. agonism; 5-HT2A antagonism; agonism. Aripiprazole: D2 partial agonist; 5-HT(2A) antagonist; counteracting the NMDA-R antagonists'. Of 17 placebo-controlled trials with olanzapine, aripiprazole, risperidone. Novi F, Millan MJ, Corsini GU, Maggio R. Partial agonist actions of aripiprazole and. Aripiprazole binds to the D2 receptor with the same affinity than dopamine. Aripiprazole as partial agonist: note that the “signal” is lower than. Telmisartan does not exhibit any partial agonist activity at the AT1 receptor. Aripiprazole is thought to act mainly by being a' partial agonist' for the receptors for. 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