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In fact aripiprazole is characterized by an original mechanism of action: it combines partial agonist activity on D2, D3 and 5-HT1A receptor with. The novel atypical antipsychotic agent aripiprazole is a partial agonist at D2 receptors that has been shown in clinical trials to be effective in treating both the. Aripiprazole binds to the D2 receptor with the same affinity than dopamine. Aripiprazole as partial agonist: note that the “signal” is lower than. new/1479-1-496.phpnew/2072-1-810.php However, the efficacy of aripiprazole could be mediated through a combination of partial agonist activity at D2 and 5-HT1A receptors and antagonist activity at. Cotard's Syndrome after breast surgery successfully treated with aripiprazole. Aripiprazole is a drug with partial agonist activity at the level of dopamine. 60 Partial Agonist (Buprenorphine) 50 40 30 20 Antagonist (Naltrexone) 10 0. attivatore) •Olanzapina (D2 – D3 agonista) •Aripiprazole (D2 – D3 agonista). 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