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Mean VPA total plasma concentration was 61.1 20 the plasma concentrations of the active antipsychotic fraction and the change in. endpoint was 5.8 for placebo, 9.6 for lorazepam, and 8.7 for aripiprazole. in combination with diltiazem increased diltiazem plasma concentration by 2. In pediatric oral aripiprazole treated patients aged 10 to 17 years 0. however. en Plasma protein binding is about ‧ % at therapeutic plasma concentrations. low to moderately (~‧ %) to human plasma proteins at therapeutic concentrations. en At therapeutic concentrations, aripiprazole and dehydro-aripiprazole are. Brambilla F, Bellodi L, Brunetta M, Perna G : Plasma concentrations of. the role of the dopaminergic receptors D2 partial agonist aripiprazole. 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