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Depression in schizophrenia: comparison of first- and second-generation. Second-generation antipsychotics (SGAs) were originally assumed to be free from. Furthermore, clozapine-, aripiprazole- and amisulpride-induced NMS can. Aripiprazole represents an interesting potential treatment for depressive and anxiety. Second-generation antipsychotics in the treatment of major depressive. arcolane ketoconazole scalp solution other than dopamine and serotonin subtypes may explain some of the other clinical effects of aripiprazole. second-generation antidepressive agent. Also for this reason, second generation drugs – showing a higher tolerability profile. olanzapine, quetiapine and aripiprazole are associated to low incidence of. In Canada, there are 7 marketed second-generation antipsychotics: Clozapine. Olanzapine, Quetiapine, Paliperidone, Ziprasidone and Aripiprazole. 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