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Symptoms not controlled on 2 drugs after dose optimization. different pacing rate. 9. de Divitiis O., Liguori V., Petitto M., Jacono C., Ferraro S., Villari B., Fazio S. Nitrendipine and atenolol: comparison and combination in the treatment of arterial. Metoprolol in hypertension: hemodynamic evaluation. Usefulness of antidepressive and beta-blocking drug in the control of. Atenolol (Definition). Atenolol is a relatively long-acting (24 hours) beta-blocker. Beta-blockers as a group of medications calm or slow the heart rate down. Rate control. 3. atenololo, metoprololo, nadololo,timololo, esmololo amiodarone, bretilio, sotalolo. vs PLA. Group A: Flecainide 100 + 50 mg + Metoprolol 50 mg x 2. 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