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Study of cholesterol lowering with simvastatin in 20536 high-risk individuals: a. J Clin Pharmacol. 2001 Jul;41(7):779-82. The effects of converting from simvastatin to atorvastatin on plasminogen activator inhibitor type-1. Ito MK(1). ACE(angiotensin converting enzyme) Inibiscono l'ACE e la vasodilatazione, diminuiscono la resistenze cardiovascolari periferiche. Simvastatina. Atorvastatina. Si riporta un caso di grave interazione tra simvastatina, amiodarone e atazanavir che ha causato rabdomiolisi e insufficienza renale acuta. (continua.) If you are taking simvastatin, grapefruit products should be avoided. 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