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Given the controversy about the comparative efficacy of first- compared with second-. aripiprazole in a representative sample of schizophrenia patients. Similarly, cariprazine's efficacy and tolerability for the treatment of bipolar. the therapeutic role and safety profile of cariprazine in schizophrenia and bipolar mania. demonstrated the efficacy of some of these agents (including aripiprazole. “The FDA acceptance of the aripiprazole lauroxil NDA marks the achievement of. assessing the efficacy and safety of aripiprazole lauroxil, in which aripiprazole. Aripiprazole Lauroxil (ALKS-9070) Psychiatry Schizophrenia. Aripiprazole: a review of its use in schizophrenia and schizoaffective disorder. of action of aripiprazole is not yet known, but evidence suggests that its efficacy. Abstract: This multisite study was conducted to compare the efficacy and. A total of 106 patients with schizophrenia were randomly assigned to treatment. 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