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Amiodarone may decrease the clearance of digoxin, resulting in prolonged. β-blockers in combination to rhythm control therapy could have the. IV amiodarone is relatively safe and more effective than digoxin for acute heart rate. Captopril versus digoxin in mild-moderate chronic heart failure: a. captopril and digoxin and their combinations in patients with severe. Amiodarone. Interaction Between Digoxin and Amiodarone Steven Haffa, RPh. Volume IX, Issue 12. Disorders of cardiac rhythm requiring antiarrhythmic therapy generally. Combined. No food or drug interaction. No need. Digoxin. (P-GP substrate). • Amiodarone. (moderate to strong P-gp inhibitor). 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