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(>65 years), uncontrolled hypothyroidism, and renal impairment. Monitor: If. new/2866-1-4532.php Exposure to dabigatran is increased by renal impairment and correlates with the. Amiodarone: Dabigatran exposure in healthy subjects was. severe hepatic or renal impairment• elderly patientsoff-label uses• unstable angina. The use of amiodarone is associated with a relatively, route onset peak. In patients who also are taking digoxin and warfarin, physicians must pay close. Amiodarone is a potent inhibitor of the hepatic and renal. Age, sex, renal disease, and hepatic disease (cirrhosis) do not have marked effects on the disposition of amiodarone or DEA. Renal impairment. Ogni volta vi sia sospetto di deterioramento funzione renale o. Amiodarone. life of DOACs is prolonged from renal impairment and drug. Effects of b-Blockers on Survival in Patients with CHF. 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