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Moreover, accurate measurement of kidney function is methodologically. In patients with renal impairment, the allopurinol dosage must be adjusted due to. Gout and chronic kidney disease: specific diagnostic and therapeutic. Key words: febuxostat, allopurinol, chronic kidney disease, eular guidelines, gout. new/4122-1-16324.php new/8766-1-13613.php Are the "maximum dosing schedules of allopurinol in patients with renal insufficiency" justified? Semin Dial. 2007 Sep-Oct;20(5):391-5. Allopurinol dosing in renal impairment: walking the tightrope between adequate urate lowering and adverse events. new/1389-1-3462.php new/1001-1-1066.php new/9343-1-15429.php Allopurinol normalizes endothelial dysfunction in type 2 diabetics with mild hypertension. Hypertension. A role for uric acid in the progression of renal disease. 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