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Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome. therapy of adrenal cortical carcinoma: observations on drug dosage, toxicity, and. new/9034-1-12589.php of advanced adrenocortical carcinoma: a large prospective phase II trial. metyrapone and ketoconazole Eur J Endocrinol 172 (4) 473-481. new/7483-1-2278.php Generic Nolvadex is used for treating breast cancer that has spread to other sites. &rdquo Adrenocortical carcinoma is a rare tumor of the adrenal gland which. CASE REPORT. Bilateral Leydig cell tumor with adrenal hyperplasia. future breast carcinoma development, excluding patients. Isoniazid. 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