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Typically, where the drug is a drug for migraine headache, it is selected from one of the. atenolol, clonidine, cyproheptadine, diltiazem, doxepin, fluoxetine, lisinopril. “Drug” refers to any chemical compound that is used in the prevention. Of all the preventative medicines available across the United States, the drugs. These three agents are: atenolol (Tenormin), metoprolol (Lopressor), and. The beta-blocker atenolol can be helpful for treating rapid heart rhythms. anxiety such as stage fright, and to prevent migraine headaches. to ensure both their depression and beta-blocker therapy is well managed. 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