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Superior cardioversion efficacy vs placebo and amiodarone. – The safety and. AF = atrial fibrillation; AFL = atrial flutter; NA = not applicable. 1. Roy D et al. Drugs include: amiodarone, ibutilide, sotalol, dofetilide, and dronedarone. For the rapid control of ventricular rate in patients with atrial fibrillation or atrial flutter. frontare la sicurezza e l'efficacia di amiodarone e dronedarone in pazienti con. vernakalant hydrochloride injection (RSD1235) in atrial fibrillation or atrial. 18) Roy D, Pratt C M. Vernakalant Hydrochloride for Rapid Conversion of Atrial Fi-. a pharmacological profile similar to Amiodarone but has a more rapid onset of. 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